The Impact of Inflammation on Cellular Aging

Research Projects

The Impact of Inflammation on Cellular Aging

Research Background Our laboratory aims to investigate the intersection of psychological stress, nutrition, and physical activity to understand how stress gets “under your skin” and contributes to disease, including cardiovascular disease and various types of cancer. To address these questions, we are conducting a number of research projects focused on telomere length, which are a […]

Read More

Exercise-induced lactate and immune cell function

Primary Investigator: Dr. Lee Franco Other Investigators: Anson Blanks Cardiovascular disease may be characterized by a skewing of macrophage polarization from the anti-inflammatory M2 phenotype towards the pro-inflammatory M1 phenotype. Lactate, a by-product of cell metabolism which is increased in circulation during intense exercise, has been shown to skew the monocyte to macrophage transition towards […]

Read More

VCU-ART3

Primary Investigator: Dr. Lee Franco Other Investigators: Anson Blanks Chronic heart failure (CHF) is often a result of myocardial damage following ST-segment elevation myocardial infarction (STEMI). This damage is due in part to the recruitment of inflammatory monocytes by activation of the CCR2 receptor. Previous studies have suggested that Anakinra, an IL-1β receptor antagonist, may […]

Read More

LPS-Induced iNOS mRNA and Pro-Apoptotic Signaling

Primary Investigator: Dr. Ed Acevedo Other Investigators: Aaron Slusher, Tiffany Zuniga This study seeks to understand the potential role of iNOS in the maintenance of cellular homeostasis and to investigate how the effect of aerobic exercise training may alter iNOS mRNA expression in leukocytes, thereby influencing the pro-apoptotic pathway to sustain cellular regulation.

Read More

PTSD, Vascular Function, and Exercise Tolerance Study

Primary Investigator: Dr. Ryan Garten This study aims to identify the impact of post-traumatic stress disorder (PTSD) on peripheral vascular function, oxidative stress/inflammation, and exercise tolerance in young individuals.

Read More

Reductive Stress Study

Primary Investigator: Dr. Ryan Garten This study examines the impact of 28 days of antioxidant supplementation on vascular function and exercise tolerance in young, healthy individuals.

Read More

Sleep Quality and CVD Risk Study

Primary Investigator: Dr. Ryan Garten The study seeks to identify the impact of sleep quality on peripheral vascular dysfunction (an early indicator of CVD).

Read More

Prolonged Sitting and Vascular Function Stud

Primary Investigator: Dr. Ryan Garten This study examines the mechanisms behind prolonged sitting-induced vascular dysfunction and how age, gender, and aerobic capacity alter the magnitude of this dysfunction.    

Read More