Primary Investigator: Dr. Lee Franco
Other Investigators: Anson Blanks
Cardiovascular disease may be characterized by a skewing of macrophage polarization from the anti-inflammatory M2 phenotype towards the pro-inflammatory M1 phenotype. Lactate, a by-product of cell metabolism which is increased in circulation during intense exercise, has been shown to skew the monocyte to macrophage transition towards the anti-inflammatory M2 phenotype in cell culture models. Lactate induced M2 skewing may help to maintain M1/M2 macrophage balance which may be a possible mechanism through which intense exercise helps to prevent the development of cardiovascular disease. The current study aims to determine the effects of exercise induced lactate accumulation in humans on several cellular processes that are known to influence the monocyte to macrophage transition as well macrophage polarization.